Changes in glucosylceramide structure affect virulence and membrane biophysical properties of Cryptococcus neoformans

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Chronological aging is associated with biophysical and chemical changes in the capsule of Cryptococcus neoformans.

Does the age of a microbial cell affect its virulence factors? To our knowledge, this question has not been addressed previously, but the answer is of great relevance for chronic infections where microbial cells persist and age in hosts. Cryptococcus neoformans is an encapsulated human-pathogenic fungus notorious for causing chronic infections where cells of variable age persist in tissue. The ...

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ژورنال

عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes

سال: 2017

ISSN: 0005-2736

DOI: 10.1016/j.bbamem.2017.08.017